全文获取类型
收费全文 | 1361307篇 |
免费 | 117670篇 |
国内免费 | 8809篇 |
专业分类
耳鼻咽喉 | 17067篇 |
儿科学 | 43285篇 |
妇产科学 | 36886篇 |
基础医学 | 186177篇 |
口腔科学 | 36793篇 |
临床医学 | 124462篇 |
内科学 | 280652篇 |
皮肤病学 | 32198篇 |
神经病学 | 111590篇 |
特种医学 | 56728篇 |
外国民族医学 | 298篇 |
外科学 | 212836篇 |
综合类 | 37817篇 |
现状与发展 | 13篇 |
一般理论 | 414篇 |
预防医学 | 107861篇 |
眼科学 | 29073篇 |
药学 | 96770篇 |
30篇 | |
中国医学 | 4007篇 |
肿瘤学 | 72829篇 |
出版年
2018年 | 14588篇 |
2017年 | 11791篇 |
2016年 | 13776篇 |
2015年 | 15829篇 |
2014年 | 21829篇 |
2013年 | 31365篇 |
2012年 | 38795篇 |
2011年 | 41554篇 |
2010年 | 25960篇 |
2009年 | 25173篇 |
2008年 | 37890篇 |
2007年 | 40385篇 |
2006年 | 41519篇 |
2005年 | 40145篇 |
2004年 | 37744篇 |
2003年 | 36732篇 |
2002年 | 34599篇 |
2001年 | 66647篇 |
2000年 | 68478篇 |
1999年 | 57114篇 |
1998年 | 16547篇 |
1997年 | 14833篇 |
1996年 | 15701篇 |
1995年 | 16561篇 |
1994年 | 15392篇 |
1993年 | 14270篇 |
1992年 | 47284篇 |
1991年 | 45956篇 |
1990年 | 44129篇 |
1989年 | 41946篇 |
1988年 | 38867篇 |
1987年 | 38158篇 |
1986年 | 35922篇 |
1985年 | 34686篇 |
1984年 | 26358篇 |
1983年 | 22078篇 |
1982年 | 13835篇 |
1981年 | 12419篇 |
1980年 | 11672篇 |
1979年 | 23513篇 |
1978年 | 17020篇 |
1977年 | 14336篇 |
1976年 | 13139篇 |
1975年 | 13694篇 |
1974年 | 16067篇 |
1973年 | 15379篇 |
1972年 | 14167篇 |
1971年 | 13023篇 |
1970年 | 11863篇 |
1969年 | 11092篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
51.
Keith P. Reber John D. Sivey Matthew Vollmuth Priyansh D. Gujarati 《Journal of labelled compounds & radiopharmaceuticals》2022,65(9):254-263
Parabens are antimicrobial additives found in a wide array of consumer products. However, the halogenated compounds formed from parabens during wastewater disinfection are a potential environmental concern. In order to identify these transformation products and investigate their mechanism of formation, a synthetic route to ethyl parabens labeled with the stable isotope carbon-13 at specific positions within the benzene ring was developed. This efficient two-step procedure starts from commercially available 13C-labeled phenols and involves (1) initial acylation of the phenol via a Houben–Hoesch reaction with trichloroacetonitrile followed by (2) a modified haloform reaction of the resulting trichloromethyl ketone to afford the corresponding 13C-labeled ethyl parabens in 65%–80% overall yield. The scope of the modified haloform reaction was also investigated, allowing for the synthesis of other parabens derived from primary or secondary alcohols, including 13C- and deuterium-labeled esters. In addition, 4-hydroxybenzoic acid can be formed directly from the common trichloromethyl ketone intermediate upon treatment with lithium hydroxide. This protocol complements existing methods for preparing 13C-labeled paraben derivatives and offers the specific advantages of exhibiting complete regioselectivity in the Houben–Hoesch reaction (to form the para-disubstituted product) and avoiding the need for protecting groups in the modified haloform reaction that forms the paraben esters. 相似文献
52.
53.
目的探讨腹腔镜食管裂孔疝修补术联合改良DOR胃底折叠术治疗食管裂孔疝(HH)合并胃食管反流病患者的临床疗效。
方法选择2016年1月至2019年1月河北北方学院附属第二医院收治的108例食管裂孔疝合并胃食管反流病患者开展回顾性研究,按照不同手术方式将患者分为2组,每组患者54例。对照组行常规开腹手术,联合组行腹腔镜食管裂孔疝修补术联合改良DOR胃底折叠术,比较2组患者术前及术后6个月反流时间、反流次数、DeMeester评分、食管下括约肌压力及Gerd Q量表评分。
结果2组术前反流时间、反流次数、DeMeester评分、食管下括约肌压力及Gerd Q量表评分比较,差异无统计学意义(P>0.05);2组患者术后6个月反流症状与术前比较,均得到明显改善,差异有统计学意义(P<0.05);2组术后反流时间、反流次数、DeMeester评分、食管下括约肌压力及Gerd Q量表评分比较,差异有统计学意义(P<0.05)。联合组患者的手术时间、术中出血量及术后住院时长均明显优于对照组,差异有统计学意义(P<0.05)。
结论腹腔镜食管裂孔疝修补术联合改良DOR胃底折叠术对HH合并胃食管反流病患者效果显著,有利于患者身体快速恢复,微创、安全且近期疗效满意。 相似文献
54.
K. El-Boghdadly T. M. Cook T. Goodacre J. Kua S. Denmark S. McNally N. Mercer S. R. Moonesinghe D. J. Summerton 《Anaesthesia》2022,77(5):580-587
The impact of vaccination and new SARS-CoV-2 variants on peri-operative outcomes is unclear. We aimed to update previously published consensus recommendations on timing of elective surgery after SARS-CoV-2 infection to assist policymakers, administrative staff, clinicians and patients. The guidance remains that patients should avoid elective surgery within 7 weeks of infection, unless the benefits of doing so exceed the risk of waiting. We recommend individualised multidisciplinary risk assessment for patients requiring elective surgery within 7 weeks of SARS-CoV-2 infection. This should include baseline mortality risk calculation and assessment of risk modifiers (patient factors; SARS-CoV-2 infection; surgical factors). Asymptomatic SARS-CoV-2 infection with previous variants increased peri-operative mortality risk three-fold throughout the 6 weeks after infection, and assumptions that asymptomatic or mildly symptomatic omicron SARS-CoV-2 infection does not add risk are currently unfounded. Patients with persistent symptoms and those with moderate-to-severe COVID-19 may require a longer delay than 7 weeks. Elective surgery should not take place within 10 days of diagnosis of SARS-CoV-2 infection, predominantly because the patient may be infectious, which is a risk to surgical pathways, staff and other patients. We now emphasise that timing of surgery should include the assessment of baseline and increased risk, optimising vaccination and functional status, and shared decision-making. While these recommendations focus on the omicron variant and current evidence, the principles may also be of relevance to future variants. As further data emerge, these recommendations may be revised. 相似文献
55.
56.
Alexander D. Sherry MD Kelsey L. Corrigan MD MPH Ramez Kouzy MD Joseph Abi Jaoude MD Yumeng Yang MS Roshal R. Patel MD Douglas J. Totten MD MBA Neil B. Newman MD MS Prajnan Das MD MS MPH Cullen Taniguchi MD PhD Bruce Minsky MD Rebecca A. Snyder MD MPH C. David Fuller MD PhD Ethan Ludmir MD 《Cancer》2023,129(21):3430-3438
57.
58.
59.
Estefany I. Medina-Reyes Carolina Rodríguez-Ibarra Daniel Díaz-Urbina Alejandro Déciga-Alcaraz Normal L. Delgado-Buenrostro Yolanda I. Chirino José Pedraza-Chaverri 《Journal of applied toxicology : JAT》2022,42(8):1411-1419
Food-grade titanium dioxide (E171) is widely used as a food additive, and it is known that after oral consumption, E171 is translocated into the bloodstream reaching the highest titanium level at 6 h. E171 is accumulated in some organs triggering toxicity, but the effects on the blood parameters after oral consumption have been less studied. Recently, evidence shows that oral exposure to E171 induces behavioral signs of anxiety and depression. The relation between blood alterations and psychiatric disorders has been previously demonstrated. However, the oral exposure to E171 effects on alterations in blood parameters and effects linked to alterations in animal behavior has not been explored. In this short communication, we aimed to investigate the effects of E171 on specific blood parameters (hematocrit, hemoglobin, number of erythrocytes, and leukocytes) and anxiety and compulsive-like behavior in males and females orally exposed to ~5 mg/kg for 4 weeks. The results showed that E171 decreased hematocrit and hemoglobin in male but not in female mice while leukocyte and erythrocyte count remained unaltered. Oral consumption of E171 decreased the levels of anxiety-like behavior in females but not in male mice, while compulsive-like behavior was increased in both male and female mice. 相似文献